Journal of Physical Studies 14(4), Article 4801 [5 pages] (2010) DOI: https://doi.org/10.30970/jps.14.4801 DOUBLE-POOL KINETIC MODEL OF SYNAPSE ACTIVATION A. N. Vasilev{1,2}, S. V. Kislyak{2} {1}Taras Shevchenko National University of Kyiv, Faculty of Physics, Department for Theoreticsl Physics, 64, Volodymyrska St., Kyiv, UA--01601, Ukraine {2}National Technical University of Ukraine ‟Kyiv Polytechnic Institute”, Intercollegiate College of Medical Engineering, Department of Biomedical Engineering, 16/2, Yanhelya St., Kyiv, UA--03056, Ukraine

In this paper we propose a model that determines the activation of synapse while the nerve impulse is spreading throughout. In particular we investigate presynaptic membrane that holds vesicles with the mediator. It injects into the synaptic cleft when the nerve impulse arrives. It is taken into account that vesicles are grouped in several pools. The mediator injection in the cleft depends on which pool the vesicle holds. In the model we also account pool-to-pool transitions of vesicles.

PACS number(s): 89.75.Fb, 87.10.+e, 87.16.Xa

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