DOI: https://doi.org/10.30970/jps.16.4802
MODELING OF POSTSYNAPTIC MEMBRANE ACTIVATION
S. I. Braichenko, A. N. Vasilev
Taras Shevchenko National University of Kyiv
60, Volodymyrska St., Kyiv, UA--01601, Ukraine,
e-mail: vasilev@univ.kiev.ua
|
Journal of Physical Studies 16(4), Article 4802 [6 pages] (2012)
DOI: https://doi.org/10.30970/jps.16.4802 MODELING OF POSTSYNAPTIC MEMBRANE ACTIVATIONS. I. Braichenko, A. N. Vasilev
Taras Shevchenko National University of Kyiv |
|
We propose a nonlinear model that describes the process of postsynaptic membrane activation while the nerve impulse is spreading through the synaptic cleft. The model accounts among other things for redistribution at the postsynaptic membrane of the mediator that is a biologically active substance due to which the membrane activation occurs. We show that diffusion mechanisms play a leading role in the process of the activation zone formation on the postsynaptic membrane. The results of numerical modeling for the activation process of the postsynaptic membrane are presented for the case when at the initial moment the mediator is localized at the center of the postsynaptic membrane.
PACS number(s): 89.75.Fb, 87.10.+e, 87.16.Xa